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Moderna–Recordati Strike Global Deal on mRNA-3927 for Propionic Acidemia

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Moderna–Recordati Strike Global Deal on mRNA-3927 for Propionic Acidemia Moderna and Recordati Partner to Bring First mRNA Treatment for Rare Metabolic Disorder to Patients BLUF (Bottom Line Up Front): Moderna has partnered with Italian pharmaceutical company Recordati to develop and commercialize mRNA-3927, an investigational mRNA-based treatment for propionic acidemia (PA)—a devastating rare genetic disorder affecting metabolism. This marks a significant expansion of mRNA technology beyond vaccines into treating genetic diseases, with the therapy currently in Phase 1/2 clinical trials. The agreement provides Moderna with up to $160 million in upfront and near-term payments, while Recordati will handle global commercialization once approved. For patients with PA and their families, this represents the first potential disease-modifying treatment for a condition that currently has only supportive care options. Understanding Propionic Acidemia: A Devastating Genetic Disorder Propion...
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Light Therapy Shows Promise as Game-Changing Prevention for Brain Injury in Contact Sports

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False-color brain images showing the average change in inflammation from the start to the end of the season within the group receiving the placebo treatment. Red corresponds to greatest increase in inflammation. Image credit: Hannah Lindsey, PhD. Groundbreaking University of Utah Research Suggests Medical-Grade Near-Infrared Technology Could Protect Athletes, Veterans, and First Responders From Cumulative Brain Damage BLUF (Bottom Line Up Front) Medical-grade near-infrared light therapy has demonstrated the ability to prevent brain inflammation in collegiate football players exposed to repetitive head impacts over a full season, according to breakthrough research published in the Journal of Neurotrauma. The technology, which uses photobiomodulation at specific wavelengths, could represent the first viable prophylactic treatment for chronic traumatic encephalopathy (CTE) and related brain injuries—a development that could fundamentally transform the safety landscape for...
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Pollyanna: From Page to Screen

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The Book and Its Enduring Legacy Eleanor H. Porter's 1913 novel "Pollyanna" introduced the world to one of literature's most optimistic characters—an eleven-year-old orphan who plays the "Glad Game," finding something to be glad about in every situation. The book became an immediate bestseller and spawned a cultural phenomenon that continues to resonate over a century later. The novel tells the story of Pollyanna Whittier, who comes to live with her stern Aunt Polly in the fictional Vermont town of Beldingsville after her missionary father's death. Armed with nothing but her father's teachings and an unshakeable optimism, Pollyanna transforms the rigid, unhappy lives of nearly everyone she meets. The narrative explores themes of positive thinking, community transformation, and the redemptive power of gratitude—though Porter's original work contains considerably more depth and nuance than popular culture's simplified "Pollyanna" s...
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